COMPOSITION OF MYELIN LIPIDS AND SYNTHESIS OF 3‐KETODIHYDROSPHINGOSINE IN THE VITAMIN B6‐DEFICIENT DEVELOPING RAT1
- 1 April 1973
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 20 (4) , 963-968
- https://doi.org/10.1111/j.1471-4159.1973.tb00066.x
Abstract
Abstract— Recoverable myelin in 20‐day‐old, Vitamin B6‐deficient rats was reduced from that in control animals. The composition of myelin lipids from deficient animals was nearly identical to that for controls except for a striking reduction in phospholipids polyunsaturated fatty acids. Enzymatic synthesis in vitro of 3‐ketodihydrosphingosine was impaired in the deficient animals; addition of the vitamin Bs cofactor to these incubation mixtures restored activity of the condensing enzyme to control levels.This publication has 21 references indexed in Scilit:
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