Degradation of Insulin by Tissue Extracts of Normal and Nephrotic Rats.

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Abstract
1. The insulin-degrading capacity of rat kidney, liver and diaphragm extracts was determined by incubating them with (a) crystalline insulin and observing blood sugar curves in intact rats following intravenous injection of the mixture and (b) I131 insulin and measuring undegraded insulin as represented by TCA precipitable radioactivity. 2. By both measurements, kidney and liver extracts from nephrotic rats were less potent than normal organ extracts in the inactivation of insulin.