Red Cell Adenylate Kinase and Phosphoglucomutase Polymorphisms in Several Population Groups in Israel

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Abstract
The genetic polymorphism of red cell adenylate kinase (AK) and phosphoglucomutase (PGM1) has been investigated in five population groups in Israel: Ashkenazi Jews, non-Ashkenazi Jews from Iraq, Yemen, North-Africa, and Arabs. The lowest frequency of the AK2 gene was observed among the Arabs (0.0247) and the highest among the North African Jews (0.0559). A heterogeneity test performed for the five population samples did not reach the level of statistical significance. The distribution of PGM genes was found to be heterogeneous. A significantly lower frequency of the PGM1 gene was observed among the Ashkenazi Jews (0.2081) than among the three non-Ashkenazi Jewish groups and Arabs (gene frequencies 0.2708–0.3198). Similar differences have been reported to exist between Mediterranean populations (Greece, Italy, Turkey) and those from Western or Northern Europe.

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