Fluid-Bed Spray Coating

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Abstract
74Fluid-bed technology1 had been in use for several decades in the chemical industry, when Wurster2 introduced this method into pharmaceutical technology in the U.S. for coating processes. Some details of the procedure used for coating tablets and drug particles were presented by Wurster3 in 1959 and by Brudney and Toupin in 1962.4 In principle, the spray of dissolved wall material was applied from the perforated bottom of the fluidization chamber parallel to the air stream onto the cores transported upwards inside a cylinder fixed in the middle of the chamber. Robinson et al.5 modified the process for coating smaller particles by spraying from the top into an upstream of fluidized particles above a converting zone.

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