The Synthesis of Spin Labeled Acetylcholine Analogs

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Abstract
With the acknowledgement that spin label techniques can yield valuable information about the environment surrounding the active sites of biologically important macromolecules, e.g. receptors, several groups1–4 have undertaken a variety of synthetic routes to develop spin labeled analogs of these important therapeutic agents. Recently, we reported the development of a spin labeled local anesthetic using the selective reducing agent, sodium cyanoborohydride. In this communication, we will discuss the synthesis of a spin labeled analog of acetylcholine and several acetylcholine type analogs.

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