A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E2AND I2ON RENAL FUNCTION AND RENIN RELEASE IN SALT-LOADED AND SALT-DEPLETED ANAESTHETIZED DOGS

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Abstract
Prostaglandin[PG]E2 and PGI2 were infused into the renal artery of either Na-loaded or Na-depleted dogs. Systemic blood pressure decreased and arterial plasma renin concentration increased in the Na-loaded dogs by infusion of PGI2 (1200 ng/min). Both compounds increased renal blood flow but PGE2 had a much more potent effect than PGI2 on increasing urine flow and Na excretion. In the Na-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min). Both compounds stimulated urine flow and renal blood flow but PGE2 induced a much larger increase in Na excretion than PGI2. PGI2 apparently exerts its actions on renal function by inducing vasodilatation whereas PGE2 also has a direct action on tubular function.

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