Nomogram to Diagnose Familial Combined Hyperlipidemia on the Basis of Results of a 5-Year Follow-Up Study
- 22 June 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 109 (24) , 2980-2985
- https://doi.org/10.1161/01.cir.0000130646.93255.86
Abstract
Background— Familial combined hyperlipidemia (FCH) is traditionally diagnosed by total plasma cholesterol and/or triglyceride levels above the 90th percentile adjusted for age and gender. In a recent study, we showed that the diagnosis of FCH on the basis of these diagnostic criteria was inconsistent in 26% of the subjects over a 5-year period. This result emphasizes the need for reevaluation of the diagnostic criteria for FCH. Methods and Results— A total of 32 families (299 subjects) were studied in 1994 and 1999. A subject was defined “truly” FCH when diagnosed FCH in 1994 and/or 1999 on the basis of traditional plasma lipid criteria. Additional lipid and lipoprotein parameters, including apolipoprotein B (apoB) and small, dense LDL, were measured at both time points. In total, 121 subjects (40%) were defined as truly FCH. Multivariate analysis revealed that absolute apoB values combined with triglyceride and total cholesterol levels adjusted for age and gender best predicted truly FCH. A nomogram incl...Keywords
This publication has 19 references indexed in Scilit:
- Small, Dense LDL and Elevated Apolipoprotein B Are the Common Characteristics for the Three Major Lipid Phenotypes of Familial Combined HyperlipidemiaArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Carotid artery intima-media thickness in Finnish families with familial combined hyperlipidemiaAtherosclerosis, 2002
- Lack of agreement between the plasma lipid-based criteria and apoprotein B for the diagnosis of familial combined hyperlipidemia in members of familial combined hyperlipidemia kindredsMetabolism, 2002
- Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: a 20-year prospective studyAtherosclerosis, 2001
- Phenotype expression in familial combined hyperlipidemiaAtherosclerosis, 1997
- Prevalence of dyslipidemic phenotypes in ischemic heart disease (prospective results from the Que´bec cardiovascular study)The American Journal of Cardiology, 1995
- Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease riskAtherosclerosis, 1994
- Familial combined hyperlipidemia in children: Clinical expression, metabolic defects, and managementThe Journal of Pediatrics, 1993
- Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertriglyceridemia.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1986
- Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIAJournal of Clinical Investigation, 1973