The Effects of 5-Azacytidine, 12-O-Tetradecanoylphorbol 13-acetate and Sodium n-butyrate on Reactivation of Alphaherpesvirus Saimiri from Explant Cultures of Latently Infected Rabbit Dorsal Root Ganglia

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Abstract
Summary The DNA hypomethylating agent 5-azacytidine greatly increased the reactivation of alphaherpesvirus saimiri-1 (αHVS) from latently infected rabbit dorsal root ganglia, although it inhibited the virus yield and plaque formation efficiency of αHVS in Vero cells. 12-O-Tetradecanoylphorbol 13-acetate (a protein kinase C activator) and sodium n-butyrate both had a stimulating action on replication in Vero cells but did not affect the release of αHVS from latently infected rabbit dorsal root ganglia.