Serological studies in Crohn's disease
- 1 June 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 6 (3) , 286-290
- https://doi.org/10.1007/bf02017614
Abstract
ELISA and immunofluorescence tests were carried out on sera from patients with Crohn's disease and ulcerative colitis. The results indicate that mean antibody levels to Yersinia enterocolitica types O∶9 and O∶3 and Klebsiella pneumoniae,but not Pseudomonas maltophilia,are significantly higher in these patients than in control subjects. There are differing antibody levels in ileal and colonic disease, and there is a significant fall in antibody levels 9–12 months after remission from clinical symptoms in patients providing serial serum samples. However, there is no correlation between the severity of the disease and antibody titres.This publication has 21 references indexed in Scilit:
- Identification of HLA-B27M1 and -M2 cross-reactive antigens in Klebsiella, Shigella and Yersinia.1984
- Is a Klebsiella plasmid involved in the aetiology of ankylosing spondylitis in HLA-b27-positive individuals?Molecular Immunology, 1983
- AN ANTIBODY AGAINST REVERTANT FORMS OF CELL-WALL-DEFICIENT BACTERIAL VARIANT IN SERA FROM PATIENTS WITH CROHN'S DISEASEThe Lancet, 1981
- Agglutinins to bacteria in Crohn's disease.Gut, 1980
- Escherichia coli antibodies in patients with inflammatory bowel disease.Gut, 1978
- Immunohistochemical studies of the formation and epithelial transport of immunoglobulins in normal and diseased human intestinal mucosa.1976
- Pathologic features of enteric infection with Yersinia enterocolitica.1974
- Radioimmunologic measurements of naturally occurring bacterial antibodies. I. Human serum antibodies reactive with Escherichia coli in gastrointestinal and immunologic disorders.1973
- THE MUSCULO-SKELETAL COMPLICATIONS OF CROHNʼS DISEASEMedicine, 1973
- ANKYLOSING SPONDYLITIS AND HL-A 27The Lancet, 1973