Phase-Transfer Catalysis: Acylation of β-Dicarbonyl Compounds
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 7 (3) , 195-199
- https://doi.org/10.1080/00397917708050736
Abstract
The alkylation of β-dicarbonyl compounds under phase-transfer conditions has been studied in detail and, in virtually all of the reported examples, the C-alkylation products have been found to predominate.1–6 Only when the reaction rate is slow is there any evidence for O-alkylation as, for example, when there is steric hindrance to the approach of the alkylating agent to the carbanionic centre.1,7 There is no record, however, of the corresponding acylation reactions.Keywords
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