YELLOW BONE MARROW EXTRACTS IN GRANULOCYTOPENIA

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Abstract
At the Milwaukee session of the American Medical Association, in 1933, Dr. C. H. Watkins of the Mayo Clinic announced that he had obtained favorable results on treating patients suffering from granulocytopenia with yellow bone marrow. He reported that a monocytosis first occurred, which was followed by a gradual increase in polymorphonuclear neutrophils. Usually a reaction occurred within twenty-four to forty-eight hours after ingestion of the bone marrow. An account of this work has not yet been published by Dr. Watkins.1 Shortly after this announcement Dr. M. J. Flipse of Miami, Fla., also obtained very encouraging results with the marrow but found that the large dose which is necessary was undesirable, and it was through his suggestion and that of Dr. Fenger of Armour & Co. that we sought to prepare an extract which would be free of the large amount of fat that is present in the refined

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