Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid.

1 January 1981

journal article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 78 (1) , 9-10
https://doi.org/10.1073/pnas.78.1.9

Abstract

Extensive chemical degradation of cobyrinic acid biosynthesized from a sample of factor III radiochemically labeled in its three methyl groups demonstrates that label is retained exclusively in the two methyl groups at positions C-2 and C-7 and confirms that the C-20 methyl group of the precursor is lost during formation of the corrin ring system.

Keywords

CHEMISTRY