EFFECT OF PH ON BLEOMYCIN-INDUCED DNA SINGLE-STRAND SCISSION IN L1210 CELLS AND RELATION TO CELL SURVIVAL

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (10) , 3839-3841
Abstract
The susceptibility of cultured L1210 [mouse leukemia] cells to bleomycin was investigated as a function of pH of the medium and was compared with DNA damage measured by alkaline elution. With increasing pH of the medium, cytotoxicity and DNA damage increased. This was observed in the effects of bleomycin on cell proliferation, colon forming ability and DNA elutability. The reduction of colony forming ability correlated with DNA single strand scission, and this correlation was independent of pH.

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