Making a vertebrate limb: New players enter from the wings
- 25 September 2001
- Vol. 23 (10) , 865-868
- https://doi.org/10.1002/bies.1126
Abstract
What initiates vertebrate limb development and induces limbs to form where they do? For several years the answer to this intriguing question has been framed in terms of a working model that limb induction depends on a dialogue between two members of the Fibroblast Growth Factor (FGF) family of intercellular signaling molecules, FGF8 and FGF10. Now, a recent paper has written roles for signals encoded by WNT genes, the vertebrate relatives of the Drosophila wingless gene, into the script.(1) BioEssays 23:865–868, 2001. © 2001 John Wiley & Sons, Inc.Keywords
This publication has 21 references indexed in Scilit:
- Fibroblast Growth Factor Receptor 2-IIIb Acts Upstream of Shh and Fgf4 and Is Required for Limb Bud Maintenance but Not for the Induction of Fgf8, Fgf10, Msx1, or Bmp4Developmental Biology, 2001
- WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick EmbryoCell, 2001
- Signal transduction by fibroblast growth factor receptorsFrontiers in Bioscience-Landmark, 1999
- MECHANISMS OF WNT SIGNALING IN DEVELOPMENTAnnual Review of Cell and Developmental Biology, 1998
- Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb BudScience, 1998
- β-catenin: a key mediator of Wnt signalingCurrent Opinion in Genetics & Development, 1998
- Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb DevelopmentCell, 1996
- Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limbNature, 1995
- Fibroblast growth factors induce additional limb development from the flank of chick embryosCell, 1995
- Protein modules and signalling networksNature, 1995