Inhibition of synaptosomal 5‐[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood
- 11 June 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 171 (2) , 280-284
- https://doi.org/10.1016/0014-5793(84)80504-9
Abstract
The inhibition of 5-[3H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (M r < 10000), and heat stable factor(s) were found to inhibit 5-[3H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.Keywords
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