Serum ^|^alpha;1-acid glycoprotein in Bovine Leukosis and Its Effects on Blastogenesis of Lymphocytes

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Abstract
Serum α1 acid glycoprotein (α1AGP) was examined in cows with bovine leukemia (BL), and compared with other diseased cows. Inhibitory effects of α1AGP isolated from a healthy cow and from a BL cow were also examined on the mitogenicity of healthy cow lymphocyte. In cows with BL and liver abscess, α1AGP was detected as several protein bands, not observed in healthy cows, at the position of isoelectric point (3.2-4.2) by plate electrofocusing. By radioimmunodiffusion, serum α1 AGP averaged 284.4±95.5 μg/ml for healthy female cows (less than 450 μg/ml in 95%) 316.7±101.3μg/ml for reared cows and 395.7±295.5 μg/ml for calves (those up to 14-day-old showed higher values compared with adults and reared cows). Cows with BL and other various diseases showed remarkably high α1AGP levels, 1021.6±1747.6 and 1116.7±858.7 μg/ml, respectively. In cows with BL, the following values showed positive correlation with serum α1AGP concentration: WBC count, lymphocyte count, sialic acid value and LDH level. The inhibitory effects of each mitogen, which was added with refined cow α1AGP and BL cow sera different α1AGP content, were revealed on the blastogenesis of healthy cow lymphocytes almost proportionally to the α1AGP concentration.

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