MAPPING OF THE STRUCTURAL GENE FOR THE 2ND COMPONENT OF COMPLEMENT WITH RESPECT TO THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX

  • 1 January 1979
    • journal article
    • research article
    • Vol. 31  (1) , 35-41
Abstract
Families were HLA typed and allotypes of the 2nd component of complement and properdin factor B [Bf] were determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meioses was 14.39 at maximum likelihood estimate of the recombination fraction of 0.02. This is related to other estimates of the distance between these 2 genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.