EXPERIMENTS ON ACTION MECHANISM OF VASCULAR SPASMOLYTIC AGENTS .2. ACTION OF NITROPRUSSIDE SODIUM, NITROGLYCEROL, PRENYLAMINE, AND VERAPAMIL AT LANTHANUM CONTRACTURE OF ISOLATED CORONARY-ARTERIES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (10) , 1359-1364
Abstract
In the isolated coronary arteries of cattle, La, after Ca depletion by EGTA [ethylene glycol bis(aminoethyl ether) tetraacetic acid] caused a contraction which was independent of the presence of extracellular Ca. Nitroprusside sodium and nitroglycerol acted strongly on this contraction relaxing in the same concentrations that were active on the K contraction. In contrast, a very low spasmolytic effect on the La contraction was demonstrable for verapamil. Prenylamine was without any statistically significant influence. Nitroprusside sodium and nitroglycerol must act by a mechanism entirely different from that of verapamil and prenylamine.

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