Stretch activated ion channels in myocytes: parameter estimation, simulations and phenomena
- 14 November 2002
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- Vol. 1 (1094687X) , 52-55
- https://doi.org/10.1109/iembs.2001.1018842
Abstract
Mechanosensitive ion channels influence the electrophysiological state of cardiac myocytes. An examination of the mechanisms of mechano-electrical coupling on cellular level by the mechanosensitive ion channels was performed. Simulations with a detailed electrophysiological model were carried out. Static stretch leaded to an increase of the resting potential and a decrease of the duration of the action potential with increasing sarcomere length. Dynamic stretch delivered a variety of phenomena depending on the duration and amplitude of the stretch. An arrhythmogenic single cell phenomenon, early after depolarisation, was observed.Keywords
This publication has 10 references indexed in Scilit:
- The influences of cardiac mechano-electrical feedback on action potential durationPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2003
- Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical modelsProgress in Biophysics and Molecular Biology, 1999
- Cardiac mechano-electric feedback in man: clinical relevanceProgress in Biophysics and Molecular Biology, 1998
- Swelling‐induced decrease in spontaneous pacemaker activity of rabbit isolated sino‐atrial node cellsActa Physiologica Scandinavica, 1998
- Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channelsCardiovascular Research, 1996
- Early afterdepolarizations in cardiac myocytes: mechanism and rate dependenceBiophysical Journal, 1995
- Modeling Mechanical-Electrical Transduction in the HeartPublished by Springer Nature ,1994
- The effects of increasing cell length on auxotonic contractions; membrane potential and intracellular calcium transients in single guinea‐pig ventricular myocytesExperimental Physiology, 1993
- Mechanoelectrical feedback in cardiac myocytes from stretch-activated ion channelsIEEE Transactions on Biomedical Engineering, 1993