Chemoradioprotection of the Rat Parotid Gland by Combined Use of WR-2721 and Ro-07-0582

Abstract
The radioprotection of the rat parotid gland by WR-2721 (DMF [dose modifying factor], 2.4) was compared to the protection with WR-2721 in combination with the hypoxic cell radiosensitizer Ro-07-0582 (DMF, 2.6). The radiosensitizer of malignant tumor cells Ro-07-0582 was compatible with and did not reduce the protection of normal tissue afforded by WR-2721.