VALUE OF THE 30 MIN ACTH‐TEST IN ASSESSING HYPOTHALAMIC‐PITUITARY‐ADRENOCORTICAL FUNCTION AFTER PITUITARY SURGERY IN CUSHING'S DISEASE

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Abstract
Adrenocortical responses to a 30 min ACTH‐test were measured before pituitary surgery and 8‐12 d, 2‐3 months and 6 months after, in 13 patients with Cushing's disease. The decrease in adrenocortical response to the short ACTH‐test performed 8‐12 d postoperatively correlated with the outcome as assessed 6 months after surgery. Adrenocortical response to ACTH became subnormal or borderline 8‐12 d after surgery in patients demonstrating postoperative HPA insufficiency. These results add further support to the value of the short ACTH‐test in assessing integrated HPA function in various clinical situations.