INHIBITION OF GROWTH OF MARROW CELLS BY CHLORAMPHENICOL

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Abstract
Summary: Addition of chloramphenicol inhibited the growth of human and murine marrow cells in tissue culture in soft agar. Human cells were less sensitive than murine cells. The degree of inhibition was dependent on concentration of chloramphenicol and varied between individuals. The logarithmic mean of the concentration causing 50% inhibition of growth was 14·3 μg/ml and the range of 2 S.D. on either side of the mean was 3 to 75 μg/ml. Addition of phenylalanine did not reverse the effect. The soft agar culture system may be a suitable model for studying acute suppression of haemopoiesis produced by chloramphenicol.

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