ULTRASTRUCTURAL STUDY OF PULMONARY BLEOMYCIN TOXICITY

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (4) , 1267-1272
Abstract
Ultrastructural electron microscopic manifestations of bleomycin A2 toxicity in the human lung were studied in 3 patients. In addition to the appearance of nucleolar fibrillar centers, an increase in menbranous, beaded, and granular nuclear bodies was found in nuclei of type 1, type 2 alveolar epithelial cells and interstitial fibroblasts in all treated patients. Few such nuclear bodies were found in specimens of untreated patients.