ON A NEW ANTIBIOTIC, GRISEOLUTEIN, PRODUCED BY STREPTOMYCES

1 January 1950

journal article
Published by Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis in Japanese Journal of Medicine

Vol. 3 (2) , 111-117
https://doi.org/10.7883/yoken1948.3.111

Abstract

Many antibiotic substances have been isolated in the field of streptomyces, and among them, aureomycin (1), xanthomycin (2), aureothricin (3, 4) and luteomycin (5) are yellowcolored. A strain which had been isolated about two years ago showed a new antibacterial spectrum which differed from those of streptomycin, streptothricin A (6), streptotjiricin B (7), grisein, chloromycetin and aureothricin. Further studies isolated a crystalline yellow antibiotic and another reddish brown antibiotic from the fermented broth. Comparing the former with descriptions of the above mentioned yellow crystalline antibiotics, the former is different from the latters. It seems to be a new antibiotic and the writers named it as griseolutein.It inhibits the growth of gram-positive and negative bacteria and it is nontoxic. In the present paper, the characters of the strains and of griseolutein are described.

Keywords

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