Antigenicity of Polypeptides (Poly-α-Amino Acids)

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Abstract
Summary: The interrelationships among a group of linear copolymers containing the amino acids, glutamic acid, lysine, alanine, tyrosine and phenyl alanine have been shown. The introduction of 5 moles % alanine into GL did not change the specificity of the molecule but the introduction of 30 moles % alanine (GLA30) resulted in a copolymer causing the production of antibody with a reactivity for all polymers listed in this study. The introduction of tyrosine into G-L (5 moles %) or G-A (10 moles %) led to antigens with some specificity directed against tyrosyl groupings, but not with enhanced antigenicity. Specificity against polyglutamic acid groupings was shown by the PCA reaction. Some heterogeneity in antibody response against the polymers has been shown by studies of diffusion in agar.

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