Antimycoplasmal activities of the speudomonic acids and structure-activity relationships of monic acid A derivatives.
- 1 January 1988
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 41 (5) , 609-613
- https://doi.org/10.7164/antibiotics.41.609
Abstract
The antimycoplasma activities of the pseudomonic acids isolated from Pseudomonas fluorescens NCIB 10586 are reported. Structure-activity relationships of a variety of ester, amide and thiol ester derivatives of the nucleus, monic acid A, are described. Enhanced antimycoplasmal activity is reported for a number of monic acid A esters and the most potent derivative, m-nitrobenzyl monate A, is a 100-fold more active against Mycoplasma hyopneumoniae than pseudomonic acid A.This publication has 0 references indexed in Scilit: