Smoking‐related dna adducts in human gastric cancers

2 December 1992

journal article
research article
Published by Wiley in International Journal of Cancer

Vol. 52 (6) , 847-850
https://doi.org/10.1002/ijc.2910520602

Abstract

DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non‐smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the ³²P‐post‐labelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/10⁸ nucleotides to 60 adducts/10⁸ nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non‐smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.

Keywords

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