Expression of IGFs and Their Receptors Is a Potential Marker for Embryo Quality
- 1 October 1997
- journal article
- Published by Wiley in American Journal of Reproductive Immunology
- Vol. 38 (4) , 237-245
- https://doi.org/10.1111/j.1600-0897.1997.tb00509.x
Abstract
PROBLEM: Insulin‐like growth factors (IGFs) and insulin have been demonstrated to stimulate oocyte maturation and embryo development. Therefore, the expression of IGFs and their receptors may be an important intrinsic factor for embryo growth and may be a potential marker for embryo quality.METHOD OF STUDY: Thirty donated day 3 embryos were cultured in vitro for an additional 3 days to observe their developmental potential and were semiquantitatively analyzed for the expression of IGF‐I, IGF‐II, IGF‐IR, IGF‐IIR, and insulin‐R.RESULTS: Our results show that the activity of these gene expressions correlates well with the morphological assessment and that high and more gene expressions were often associated with embryos of high growth potential.CONCLUSION: The IGF system may indeed play an important role in human embryogenesis; IGF gene expressions can be a good indicator of embryonic developmental stage and/or growth potential; finally, the IGF system can serve as a marker for embryo quality.Keywords
This publication has 31 references indexed in Scilit:
- Menstrual cycle specific expression of epidermal growth factor receptors in human fallopian tube epitheliumJournal of Endocrinology, 1995
- Effect of IGF‐I on pig oocyte maturation, fertilization, and early embryonic development in vitro, and on granulosa and cumulus cell biosynthetic activityMolecular Reproduction and Development, 1994
- Possible roles of insulin and insulin-like growth factors in rat preimplantation development: investigation of gene expression by reverse transcription-polymerase chain reactionReproduction, 1994
- Expression of insulin-like growth factor-I (IGF-I) in the rat fallopian tube: possible autocrine and paracrine action of fallopian tube-derived IGF-I on the fallopian tube and on the preimplantation embryoEndocrinology, 1993
- Differential expression of messenger ribonucleic acids encoding insulin- like growth factors and their receptors in human uterine endometrium and deciduaJournal of Clinical Endocrinology & Metabolism, 1993
- The embryonic pattern of rat insulin-like growth factor-I gene expression suggests a role in induction and early growth of the liverEndocrinology, 1992
- IGF-2 stimulates growth and metabolism of early mouse embryosMechanisms of Development, 1992
- Insulin‐like growth factor‐1 stimulates growth of mouse preimplantation embryos in vitroMolecular Reproduction and Development, 1992
- Expression of the insulin‐like and platelet‐derived growth factor genes in human uterine tissuesMolecular Reproduction and Development, 1990
- Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human FetusScience, 1987