Developmentally Regulated in vitro Phosphorylation of Cytoskeletal Proteins of the Cerebral Cortex of Normal and Malnourished Rats

2 November 1994

journal article
Published by S. Karger AG in Developmental Neuroscience

Vol. 16 (1-2) , 38-43
https://doi.org/10.1159/000112085

Abstract

In this investigation we studied developmentally regulated endogenous protein kinase activity in cytoskeletal proteins in the cerebral cortex of rats and the effect of early malnutrition imposed on dams on the pattern of ³²P incorporation into the cytoskeleton of pups. Our results indicated that in vitro incorporation was maximum in 7-day-old pups for both normal and malnourished groups, decreasing with development, and reaching minimum values in adult animals. However, ³²P incorporation into NF-M and tubulin was significantly lower in 7-day-old malnourished pups than in normal pups.

Keywords

CEREBRAL CORTEX
CYTOSKELETON
PHOSPHORYLATION

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