Evidence for Two Molecular Forms of Streptococcal Erythrogenic Toxin
- 1 November 1969
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 11 (1) , 160-164
- https://doi.org/10.1111/j.1432-1033.1969.tb00754.x
Abstract
Two molecular forms of streptococcal erythrogenic toxin have been isolated by DEAE‐cellulose chromatography.These two forms exhibit the same biological and immunological properties. They have the same sedimentation coefficient s20= 2.52. Molecular weight is about 30 000. The protein is made of a single polypeptide chain with glutamic acid as N‐terminal amino acid.Exposure to 2‐mercaptoethanol induces conversion to a single form.The possibility that the different molecular forms arise from the binding of small molecules of different charge through a sulfhydryl group of the protein is discussed.Keywords
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