Secretin
- 1 October 1932
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
- Vol. 111 (773) , 429-436
- https://doi.org/10.1098/rspb.1932.0066
Abstract
Secretin may be prepared from the duodenal mucous membrane by extraction with absolute alcohol, precipitation by dilute acid, and resolution in acid alcohol and precipitation by acetone. The yield of secretin is about 10 mgm. from 500 gm. of mucous membrane. The intraven. injection of 0.02 mgm. of secretin caused the secretion of about 40 drops of pancreatic juice in a cat. Secretin is a white amorphous powder, soluble in water and alkali but insoluble in acid, acetone, ether and chloroform; it has the percentage composition of a protein, and is rapidly destroyed by trypsin. Aqueous solutions do not dialyze through a collodion membrane. The physiological actions of secretin are: (a) the production of a large volume of pancreatic juice, (b) the contraction of intestinal muscle, and (c) the secretion of a small quantity of bile. Secretin is excreted in the bile and urine after the injection of comparatively large quantities into the blood.This publication has 0 references indexed in Scilit: