Metronidazole (‘Flagyl’): Mechanisms of Radiosensitization
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 26 (6) , 557-569
- https://doi.org/10.1080/09553007414551591
Abstract
Radiation biochemical and bacterial studies have been undertaken to investigate possible mechanisms of radiosensitization by metronidazole. It is concluded that the nitro-group plays a major role in its action and that at least four mechanisms may be operative under hypoxic conditions. (i) enzyme-catalysed depletion of nucleophiles, (ii) fixation of organic radicals, (iii) interference with recombination reactions, (iv) formation of toxic products.Keywords
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