Electrophoretic Variants of 6-Phosphogluconate Dehydrogenase (6PGD) and Phosphohexose Isomerase (PHI) in Different Racial Groups in Malaysia

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Abstract
Electrophoretic variants of 6PGD and PHI were studied in adults and newborns of four racial groups in Malaysia. In adults the AC phenotype of 6PGD was found in 6.0% of 581 Malays, 5.7% of 435 Chinese, 2.7% of 366 Indians, and 9.6% of 553 aborigines (12.8% of 86 Temiar, 7.5% of 214 Semai, and 10.3% of 253 of a miscellaneous group). In newborns 8.9% of 463 Malays, 8.1% of 494 Chinese, and 5.6% of 430 Indians had the AC phenotype. A rare variant similar to the Thai variant was found in a Malay adult patient and relatives and in one Chinese newborn. PHI variants are rare. Of 923 newborns only 2 of 317 Malays and 1 of 280 Chinese had the phenotype PHI 4–1, and 1 of 120 Indians had an undetermined phenotype. In adults the phenotypes 3–1 and 4–1 were each found only once in 262 Malays and 4–1 once in 265 Chinese and once in 147 Indians.

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