Evidence for a new lymphocyte‐stimulating determinant (Lsd) detected by alloreactive T cell lines
- 1 January 1983
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 13 (1) , 24-30
- https://doi.org/10.1002/eji.1830130107
Abstract
Three alloreactive T cell clones are described which reveal a new lymphocytestimulating determinant (Lsd) controlled by a gene on chromosome 1 of the mouse but different from and possibly centromeric to Mls. Two clones were originally isolated as anti-H-2b-specific and showed and retained cross-reactivity to Lsd (clone OD3, BALB/c anti-C57BL/6; clone KB37, B10.BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known.Keywords
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