Acrylonitrile Metabolism in the Rat
- 1 January 1980
- book chapter
- Published by Springer Nature
- Vol. 4, 322-324
- https://doi.org/10.1007/978-3-642-67729-8_66
Abstract
Acrylonitrile (AN) is metabolized by an oxidative pathway via glycidonitrile and glycolaldehyde cyanohydrin to cyanide (CN−), which is transformed to thiocyanate. The major route of AN metabolism (more than 2/3), however, proceeds via cyanoethylation of glutathione, to N-ace-tyl-S-(2-cyanoethyl)cysteine (AN-mercapturic acid) as a final product.Keywords
This publication has 2 references indexed in Scilit:
- Biochemical studies of toxic agents. 15. The biosynthesis of ethylmercapturic acid sulphoxideBiochemical Journal, 1964
- Determination of Cyanide, Thiocyanate, and Alpha-Hydroxynitriles in Plasma or SerumAnalytical Chemistry, 1955