Steps toward an Understanding of Chronic Granulomatous Disease

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Abstract
Chronic granulomatous disease might be regarded as an "experiment of nature," though the experiment is uncontrolled. The quest for knowledge about the disease has certainly spurred acquisition of information about the mechanisms by which white cells ingest and kill bacteria. Chronic granulomatous disease is an inherited disorder that occurs mainly in children. More accurately, as made clear in a paper by Segal et al. in the current issue,1 it is a set of diseases in which the leukocytes, particularly granulocytes, fail to perform their function of killing invading microbes (and for that matter, of dealing with certain tumor cells or . . .

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