Hemodynamic factors that affect calculated orifice areas in the mitral hancock xenograft valve.

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Abstract
From June 1974 to December 1978, 714 Hancock valves have been placed in 605 patients. One hundred seventy-five patients with a mitral xenograft have been restudied. The results were questionable due to the wide scatter and disparity between the calculated and the theoretical orifice of each valve size. To elucidate these differences, the hemodynamic data of 40 isolated, normal functioning mitral Hancock valves were reviewed. Early, middle and late diastolic mitral valve gradients were measured by planimetry and their corresponding flows were estimated by angiography. The paired data were fitted to exponential functions and specific lines for each Hancock valve size were obtained. By superimposing Gorlin's pressure and flow curves on these lines, the instantaneous effective orifice for each Hancock valve can be determined. We concluded that 1) the Hancock valve effective orifice is flow related and always lower than its theoretical opening; 2) normal function frequently cannot be firmly established by the mean effective area; and 3) the nomogram described may help in determining the time-related variations of a particular valve.