The Effects of Androsterone, Oestradiol,and Thyroid Hormone on the Artificial Premature "Climacteric" of Pure Gonadal Origin Produced by Ovariectomy in Rats: II. Effects on Histologic Structure of Liver and Kidneys
- 1 July 1946
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Gerontology
- Vol. 1 (3 Part 1) , 336-344
- https://doi.org/10.1093/geronj/1.3_part_1.336
Abstract
In experiments made on 108 ovariectomised and 11 normal rats, it was found that the administration of three hormones—thyroid, androsterone, and estradiol—was effective in delaying or reversing the decrease in relative weight of the liver and kidney which occurs as a result of the artificial climacteric produced by ovariectomy and/or as a result of natural aging. Thyroid was found to stimulate cell reproduction, which had been decreased by ovariectomy, while androsterone and estradiol increased the size of the cells without apparent effect on the number of mitoses. In the artificial climacteric in the rat, the three hormones appeared to be effective in preventing hypoplasia of the liver and kidney cells and in producing an enlargement of the liver and kidneys above the level found in normal animalsKeywords
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