Follow-up study of thymomas with special reference to their clinical stages

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Abstract
Follow-up data were obtained for 96 cases of thymoma. The 1-yr survival rate was 84.3%, the 3-yr 77.1%, the 5-yr 74.1% and the 10-yr 57.1%. The 5-yr survival rate of total resection group was 88.9%; that of non-radically treated group was 44.4%. Clinical stages were defined: stage I-macroscopically encapsulated and microscopically no capsular invasion; stage II-1. macroscopic invasion into surrounding fatty tissue or mediastinal pleura, or 2. microscopic invasion into capsule; stage III-macroscopic invasion into neighboring organ; stage IVa-pleural or pericardial dissemination; stage IVb-lymphogenous or hematogenous metastasis. Five-year survival rates of each clinical stage were 92.6% in stage I, 85.7% in stage II, 69.6% in stage III and 50% in stage IV. Recurrence after total resection was found in 6 of 69 cases. Seven of 13 patients treated by subtotal resection survived > 5 yr with postoperative radiotherapy.

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