DOUBLE-BLIND COMPARISON OF PIVMECILLINAM PLUS PIVAMPICILLIN (MIRAXID) WITH PIVAMPICILLIN ALONE IN CHRONIC-BRONCHITIS - A DANISH MULTI-CENTRE STUDY

  • 1 January 1983
    • journal article
    • research article
    • Vol. 3  (6) , 422-428
Abstract
A double-blind, multi-center trial was carried out in 62 patients with purulent exacerbations of chronic bronchitis to compare the efficacy and tolerance of pivmecillinam plus pivampicillin with that of pivampicillin given alone. Patients were allocated at random to receive treatment with 100 mg pivmecillinam plus 125 mg pivampicillin or 250 mg pivampicillin 3 times daily for 7-14 days. A satisfactory clinical response was observed in 28 (88%) of the 32 patients given pivmecillinam/pivampicillin. Of the 30 subjects taking pivampicillin alone, 22 (73%) responded to therapy. Combination therapy was more effective in rendering purulent sputum mucoid. After treatment was completed, fewer pathogens including pneumococci, Haemophilus influenzae and Enterobacteriaceae were present in the sputum of patients given the combination (4 of 14 cases) when compared to subjects who took pivampicillin alone (10 of 15 cases). Both treatments were well tolerated. One patient taking pivmecillinam/pivampicillin and 5 subjects given pivampicillin reported mild gastrointestinal discomfort.

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