The Fas Antigen and Fas-Mediated Apoptosis in B-Cell Differentiation
- 1 January 1998
- journal article
- review article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 28 (5-6) , 483-489
- https://doi.org/10.3109/10428199809058355
Abstract
In the B-cell lineage, Fas, a type 1 membrane protein belonging to the tumor necrosis factor receptor (TNF) family, is expressed on B-cells at a restricted developmental stage and on activated B-cells, but not on naive mature B-cells. Apoptosis mediated by Fas-Fas ligand interactions may be involved in the peripheral elimination of autoreactive B-cells and in the regulation of the immune response through deletion of B-cells activated by foreign antigens, as for the T-cell lineage. Fas-mediated apoptosis associated with B-cell activation is affected by costimulation through other accessory signaling molecules like CD40, whose ligands are on T-cells.Keywords
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