FACTORS AFFECTING ANTIBIOTIC CONCENTRATIONS IN BLADDER URINE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 17  (6) , 484-486
Abstract
High, but transient, antibiotic levels are achieved in bladder urine if a rapidly excreted agent is given to a patient with frequency of micturition and a normal residual bladder volume. Lower, but more prolonged levels are achieved if the drug is slowly excreted, if micturition is infrequent, or if the residual volume is increased. The magnitude of these effects was calculated mathematically for various combinations of circumstances. Such considerations have implications for treatment, particularly with drugs, such as the .beta.-lactam group, that are rapidly excreted into urine.

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