Reactivation by cysteamine of vascular α adrenoceptors blocked by the tetramine disulfide benextramine and interaction of benextramine with phenoxybenzamine
- 1 December 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 58 (12) , 1490-1493
- https://doi.org/10.1139/y80-224
Abstract
The tetramine disulfide benextramine irreversibly blocked the noradrenaline[norepinephrine, NA]-induced contraction of the isolated rabbit aorta in a manner similar to that observed with phenoxybenzamine. Cysteamine abolished the benextramine blockade but not the phenoxybenzamine blockade. Incubation of aortic tissue with benextramine prior to phenoxybenzamine exposure and followed by cysteamine treatment led to a recovery of the NA response that depended on the benextramine. Thus benextramine protected the .alpha.-adrenoceptors against phenoxybenzamine blockade.This publication has 0 references indexed in Scilit: