EXTRAEMBRYONIC TISSUE INHIBITS THE IMMUNIZING CAPACITY OF FOREIGN RED CELLS
- 1 July 1975
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 20 (1) , 82-83
- https://doi.org/10.1097/00007890-197507000-00017
Abstract
Antirat RBC [red blood cell] hemolysin titers of mice were markedly reduced by prior incubation of the RBC with trophoblast or yolk sac from rat embryos. Tissues near these structures exhibited a slight inhibitory action, whereas, in general, neither maternal nor embryonic tissues inhibited the anti-RBC response. The inhibitory effect of EET [extraembryonic tissues] is mainly attributable to its action on the antigenicity of RBC. The effect was nondialyzable, but cellular activities which can be inhibited by iodoacetic acid were not necessary for the developing inhibition. Intact RBC derived from rat embryos induced a significantly smaller hemolysin response than adult RBC.This publication has 1 reference indexed in Scilit:
- A and B Antigens of the Human Foetal ErythrocyteBritish Journal of Haematology, 1962