Abstract
An unfractionated extract of sheep pituitary gland was injected intravenously into 96 cows with cystic ovaries. Eighty-one of these animals showed nymphomania at the time treatment was begun, but the symptoms disappeared in 72 after a single injection. Symptoms recurred during the observation period in 14 of them. Six of these recurrences were from the 12 animals that showed uterine or tubal pathology. Corpora lutea are known to have been formed in 74 of the 96 animals within 31 days after treatment. Normal estrus has been shown by 69 of them since the single injection. Of the 53 animals bred following a single injection out of 84 showing no recognized uterine or tubal pathology 36 have become pregnant. Six of the 12 animals showing abnormalities of the genital tract have been bred but none have become pregnant. Re-treatment of 16 animals either because the cysts persisted after the first injection or because they recurred sometime later resulted in 6 additional pregnancies, all among the animals with normal genital tracts. A third injection was given to 3 animals but resulted in no pregnancies. Evidence is introduced in the discussion to the effect that these results show a positive action of the pituitary gonadotrophin upon cystic ovaries. Copyright © . .