Novel Variant ( bla VIM-4 ) of the Metallo-β-Lactamase Gene bla VIM-1 in a Clinical Strain of Pseudomonas aeruginosa
Open Access
- 1 December 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (12) , 4026-4028
- https://doi.org/10.1128/aac.46.12.4026-4028.2002
Abstract
A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla VIM-4 , a novel variant of bla VIM-1 , with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.Keywords
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