In vitro release of chloramphenicol from poly[N-(2-hydroxypropyl)methacrylamide] carriers by Cathepsin B

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Abstract
It has been shown in recent years that copolymers of N-(2-hydroxypropyl)methacrylamide may be used as targeted polymer drug carriers. The wide-spectrum antibiotic chloramphenicol has been bound to these carriers by means of biodegradable oligopeptidic sequences. The rate of drug release from the carrier in aqueous buffer solutions pH 7·4 and 6·0 was measured and the rates were compared with that of the enzymatic drug release from the carrier by means of the enzyme Cathepsin B. It was shown that the active drug may be released from the carrier by simple hydrolysis or by acting with an enzyme and that the rate of drug release depends on the structure of the oligopeptidic sequence which acts as a link between the drug and the polymer. The results obtained may be employed in the synthesis of a polymer compound potentially possessing antimicrobial activity.

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