THE LOCALIZATION OF I131-LABELED TRIIODOTHYRONINE AND THYROXINE IN THE PITUITARY AND BRAIN OF THE MALE GUINEA PIG1

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Abstract
The brains and pituitaries of guinea pigs injected with I131-labeled triiodothyronine showed an active concentration of radioactive material identifiable as triiodothyronine. In the brain the labeled hormone was found by autoradiographic procedures to be primarily in the nuclear areas, with the greatest accumulations occurring in the neurosecretory regions. The anterior pituitary lobe was consistently more active in concentrating the injected material than was the posterior lobe. When I131-iabeled thyroxine was injected, the brain and both pituitary lobes were able to concentrate only very small amounts of the labeled hormone, the anterior lobe appearing to concentrate the hormone as readily as the posterior lobe.

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