Brief Communication: Increased Immunogenicity of Two Lymphoma Lines After Drug Treatment of Athymic (Nude) Mice

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Abstract
Highly immunogenic subllnes of L1210 and LSTRA lymphomas were obtained from athymlc (nude) mice treated with 4(5)-(3,3-dlmethyl-1-triazeno)imidazole-5(4)carboxamide (DIC) in vivo. Conventional mice, compatible with the parent tumor, rejected the DIC-treated subllnes and were relatively resistant to a subsequent challenge with the parent lines. The DIC-treated sublines were not rejected by athymic mice, which indicated that the transplantation resistance to these tumors in conventional mice was thymus-eell dependent. In addition, there was marginal or no increase of tumor-cell immunogeniclty when the parent lines were passaged in nude mice without DIC treatment. This indicated that the DIC-dependent immunogenic changes in DIC-treated leukemic conventional mice could not be ascribed merely to protection by naturally occurring antigenic clones that resulted from DIC-induced immunodepression.

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