Shear Stress Inhibits H 2 O 2 -Induced Apoptosis of Human Endothelial Cells by Modulation of the Glutathione Redox Cycle and Nitric Oxide Synthase
- 1 December 1997
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 17 (12) , 3588-3592
- https://doi.org/10.1161/01.atv.17.12.3588
Abstract
Physiological levels of shear stress reduce endothelial cell turnover and exert a potent antiatherosclerotic effect. Here we demonstrate that oxidative stress-induced apoptosis of human en...Keywords
This publication has 19 references indexed in Scilit:
- Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like ProteasesThe Journal of Experimental Medicine, 1997
- Shear stress inhibits apoptosis of human endothelial cellsFEBS Letters, 1996
- Reactive oxygen species and programmed cell deathTrends in Biochemical Sciences, 1996
- Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.Journal of Clinical Investigation, 1996
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature, 1995
- Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.Journal of Clinical Investigation, 1995
- Oxidized LDL and lipoprotein(a) stimulate renin release of juxtaglomerular cellsKidney International, 1995
- Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.Journal of Clinical Investigation, 1993
- Hypercholesterolemia increases endothelial superoxide anion production.Journal of Clinical Investigation, 1993
- Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aortaAtherosclerosis, 1973